Utilizing Targeted Therapy to Block Triple-negative Breast Cancer Cell Colonization

Triple-negative (estrogen receptor [ER]/progesterone [PR]/human epidermal growth factor 2 [HER2]-negative) breast cancer (TNBC) is a highly aggressive subtype of cancer. Approximately 34% patients will experience distant recurrence within 3 years and eventually develop the chemotherapy-resistant, incurable disease. Therefore, development novel treatments necessary. Accumulating data demonstrate that microRNA (miR)-146a, which part miR-146 family, inhibits cell proliferation, invasion, metastasis in human cancers, including cancer, suggesting miR-146a functions as tumor suppressor cells. Our group demonstrated negatively regulates NF-κB activation to inhibit TNBC. Furthermore, our suggested suppresses TNBC colonization through cellular transfer by exosomes at sites, highlighting miR-146a-mediated crosstalk between cells microenvironment colonization. The from studies not only provide therapeutic approach prevent but also identify new signaling pathway responsible for metastasis. Since support suppressive role metastasis, thus, may have potential block sites. We seek test value prevention or treatment No conflict interest.